Power of Music

Music is somewhat a synonym to love for me. Music can make you dance, sing, laugh and even weep. This power of music led a simple man to reside in the heart of millions of people

Interested in Hinduism???
This site contains a lot of information on Hinduism sacred wealth.
http://www.sacred-texts.com/hin/index.htm

All those fascinated by RNA might find this site a jewel. I was surprised, it contains lots of information.
http://www.imb-jena.de/RNA.html

RNA-guided Epigenetic Control of Gene Expression

As little as 10% of the genome is coding DNA. The rest of the genome is non-coding and is comprised of a diverse family of repeating sequences (e.g. cen, mat, IES). These DNA repeats are foci for the generation and accumulation of short heterochromatic RNA (shRNAs). shRNAs are important for the regulation of heterochromatin initiation and formation. Double stranded shRNAs undergo RNAi-like processing involving dicer (dcr), RdRp (RNA dependent RNA polymerase), argonaute (ago) and Twi1 (piwi-related gene of the argonaute family). The processed shRNA is thought to interact with Chromo domain containing proteins (e.g. Chp1, Pdd1). The resultant complex is the molecular link between DNA target sequence (through pairing with the shRNA), HP1 (Heterchromatin Protein 1), histone H3 methylation and DNA methylation. (Black: genomic region. Purple: DNA repeats. Green: a gene or transcription unit (green). Blue: Promoter-driven mRNA. Dashed blue: intergenic transcription.)

http://www.sigmaaldrich.com/Area_of_Interest/Life_Science/Cell_Signaling/

Key_Resources/Pathway_Slides__Charts/Epigenetic_Control.html

Black holes are thought to form from stars or other massive objects if and when they collapse from their own gravity to form an object whose density is infinite: in other words, a singularity. During most of a star's lifetime, nuclear fusion in the core generates electromagnetic radiation, including photons, the particles of light. This radiation exerts an outward pressure that exactly balances the inward pull of gravity caused by the star's mass. As the nuclear fuel is exhausted, the outward forces of radiation diminish, allowing the gravitation to compress the star inward...
http://archive.ncsa.uiuc.edu/Cyberia/NumRel/BlackHoleFormation.html

In 1977, a surprising phenomenon was discovered — introns. These are sequences of DNA, within genes, which have no apparent purpose. The genes containing them were called "split genes." You could think of introns as long commercials, in a language you don't understand, interrupting your favorite television show right in the middle of the action. Introns are rare within prokaryotic cells. They are rare within the nuclear genomes of single-celled eukaryotes. However, within the cells of multicelled animals and plants almost every gene has introns.....
http://www.panspermia.org/introns.htm

Exploring the Dark Matter of the Genome

June 18, 2007 - Not so long ago, the difficult-to-sequence, highly repetitive, gene-poor DNA found in regions of chromosomes known as heterochromatin was called "junk." Like dark matter in the universe, the true nature of heterochromatin was unknown.

Now members of the Drosophila Heterochromatin Genome Project (DHGP), headed by Gary Karpen of the Department of Energy's Lawrence Berkeley National Laboratory, are approaching a complete assembly, mapping, and functional analysis of those portions (other than simple repeats) of the heterochromatic DNA of Drosophila melanogaster, the fruit fly. The results confirm that heterochromatin is far from mere junk.

"Most researchers thought heterochromatin had little or no function, because it appeared to lack the protein-coding genes that occur so richly in the chromosomes' more accessible and better-studied euchromatin," says Karpen, a senior scientist in Berkeley Lab's Life Sciences Division and an adjunct professor of cell and molecular biology at the University of California at Berkeley. "In recent years it has become apparent that heterochromatin is critical for many essential functions...... http://www.brightsurf.com/news/headlines/31165/Exploring_the_Dark_Matter_of_the_Genome.html

Tour to Han river

Sweet Memories

Adios Buddies!


Enjoying a Korean night


Merry making at Chongechong

Those sweet moments with Prof. Kwon

Dinner party thrown by Prof. Young Guen Kwon for farewell

Farewell moment with Jeong Ki Min and Chei

Who is handsome?

Me and Prabhat in front of the King's Palace, Seoul

Reciprocal Role of DKK1 and DKK2 in Vascular

Reciprocal Role of DKK1 and DKK2 in Vascular Development

Vijayendra Agrawal, Jeong-Ki Min and Young-Guen Kwon.

Department of Biochemistry, College of Natural Sciences, Yonsei University, Seoul, Korea

Abstract

The angiogenic process involves diverse cellular actions such as remodeling of extracellular matrix (ECM) and proliferation, migration, and morphogenetic differentiation of ECs. The current study was undertaken to scrutinize the genetic transformation during morphogenic differentiation in vitro and in vivo. DNA chip microarray analysis divulged the involvement of numerous genes, which were upregulated and/or downregulated with morphological transformation of ECs on two-dimensional Matrigel. Amongst hordes of altered genes, reciprocal expression of dickkopfs (DKK1 and DKK2; regulators of Wnt signalling pathway) was tracked during ECs morphogenesis. Down regulation of DKK1, whereas upregulation of DKK2 was substantiated during ECM recognition and morphological revolutionization of ECs. In vivo studies unveiled abeyant blood vessels development in DKK1 transgenic mouse embryos, while ameliorated vascular augmentation was affirmed in DKK2 transgenic mouse embryos. These affirmations insinuate that DKKs may serve as prime regulators of EC morphogenesis and vascular development.